منابع مشابه
Characterization of continuous convective powder mixing processes
The Process Analytical Technology (PAT) initiative has encouraged the development of new technology to improve upon the current manufacturing paradigm. As a result substantial attention has recently focused on continuous processing due to the ability to control disturbances online, avoiding the loss of processing materials and enabling effective process scale-up. In this paper, a pharmaceutical...
متن کاملCharacterizing powder mixing processes utilizing compartment models.
Powder mixing has been the subject of substantial research due to its importance in a variety of industrial sectors, including pharmaceuticals, food, and polymer manufacturing. Although a number of different models have been proposed in the literature, most of them are either empirical or require computationally intensive calculations that make them difficult to implement for realistic systems....
متن کاملDEM Analysis of Particle Adhesion during Powder Mixing for Dry Powder Inhaler Formulation Development
Understanding the adhesive interactions between active pharmaceutical ingredient (API) particles and carrier particles in dry powder inhalers (DPIs) is critical for the development of formulations and process design. In the current study, a discrete element method (DEM), which accounts for particle adhesion, is employed to investigate the attachment processes in DPIs. A critical velocity criter...
متن کاملOptimizing continuous powder mixing processes using periodic section modeling
While continuous powder mixing has been an area of active research in recent years, effects of operating conditions on the mixing performance has not been well understood yet. Based on our previously developed periodic section modeling (Gao et al., 2012), this paper examines the effects of operating conditions on two significant parameters of the continuous blending processes: axial velocity an...
متن کاملThe Effect of Powder Mixing Procedures on α- SiAlON
Various procedures of mixing starting powders for hot-pressing α-SiAlON ceramics were studied. They included different milling methods (attrition milling, ball milling, and sonication), liquid medium (water, isopropyl alcohol, and pyridine), and atmospheres (ambient air and nitrogen). These mixing procedures resulted in markedly different densification behavior and fired ceramics. As the powder...
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ژورنال
عنوان ژورنال: Polymer Engineering and Science
سال: 1976
ISSN: 0032-3888,1548-2634
DOI: 10.1002/pen.760161002